Endocrine Abstracts

Background: The purpose of this study was to investigate the occurrence of autoimmune thyroid disease in children and adolescents at onset of type 1 diabetes mellitus (T1DM) and to assess whether the presence of diabetes-specific autoantibodies may predict the autoimmune thyroid disorder.Methods: Seventy-three children with T1DM were recruited in the study. Glutamic acid decarboxylase antibodies (GADA), Islet cell antibodies (ICA), insulin autoantibodies...

Background: Bilateral total adrenalectomy (TA), despite causing persistent adrenal insufficiency with lifetime replacement of corticosteroids, is the method of choice in patients with bilateral pheochromocytoma. Partial adrenalectomy (PA) is an alternative approach that aims to balance tumor removal while maintaining adrenal function, although the oncological completeness of the procedure is questionable.Objective: The aim of this systematic review and m...

Background: The development of thyroid dysfunction is a frequent side effect associated to sunitinib therapy but scanty data are available on thyroid function on long-term sunitinib-treated patients.Objective: Prospective evaluation of 28 patients suffering from mRCC treated with sunitinib, enrolled between September 2013 and October 2015. 28 patients (24 men and 3 women (median age 57.7, range 51–77)) with comparable tumor staging, normal thyroid f...

Aim: To investigate the possible association of the rs9939609 polymorphism in the FTO gene with obesity in the Republic of Tatarstan (RT).Materials and methods: The study involved 63 adult patients (21 men and 42 women; 38–77 years old) with overweight or obesity and 515 healthy young people (157 men and 358 women; 16–35 years old) with normal weight. We assessed clinical and biochemical parameters (blood lipid profile). The analysis of the rs9...

It is known that glucose disturbances contribute to vascular ageing. The length of telomere (TL) and telomerase activity (TA) are considered as biomarkers of cellular ageing. It is crucial to determine the role of telomere biology in different vessels changes in diabetic patients. The aim of our study was to determine the role of telomere biology in vascular ageing in patients with T2DM.Results: All patients were divided into two groups by the median of ...

Insulin pump is one of the treatment options for patients with type 1 diabetes mellitus. In July 2008, NICE has issued Technological Appraisal (TA 151) regarding insulin pump therapy guidance.Objective of the audit: To measure current practice in Colchester General Hospital in continuous subcutaneous insulin infusion – CSII (insulin pump) for the treatment of diabetes mellitus against the recommendations in the technological appraisal (TA 151).<...

Aim: In this study, we aimed to determine the strain index (SI) as well as the ES scoring of thyroid nodules, and establish the role for these parameters in the differential diagnosis of thyroid nodules using histopathological analysis as a reference standart.Materials and method: Real-time ES in transverse axis (TA) and longitudinal exis (LA) was performed in 391 nodules of 292 patients. ES scoring was made for all the nodules. SI in TA and LA was calcu...

Steroidogenic cells of the adrenal cortex are thought to originate from a peripherally-located self-renewing population of undifferentiated stem or progenitor cells. These cells divide infrequently to give daughters, which proliferate transiently (termed transiently amplifying (TA) cells), migrate and differentiate to replenish the functionally-differentiated zones of the adrenal cortex, or remain in situ as undifferentiated stem cells. Theoretically such stem cells can...

Hexose-6-phosphate dehydrogenase (H6PD) is a sarcoplasmic reticulum (SR) resident enzyme that metabolizes glucose-6-phosphate and generates NADPH that drives the activation of glucocorticoids by 11β-hydroxysteorid dehydrogenase type 1. H6PD KO mice exhibit improved skeletal muscle insulin sensitivity increased glucose uptake and glycogen storage. However, H6PD KO mice also develop a myopathy with switching from Type II to Type I fibers. Affected muscles have apparently no...

A baby was born at 32 weeks with a birth weight of 1.59 kg. Mother had complex medical history including diabetes mellitus, chronic hypertension, nephropathy, maculopathy, ischaemic stroke on aspirin, hyperthyroidism and polycystic ovarian syndrome. Antenatal scan showed ambiguous genitalia with clitoromegaly and mother had bilateral adnexal multi-separated cysts. Baby was born by emergency lower segment cesaerean section due to pre-clampsia and biopsy of mother adnexal mass w...